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Article

Oligogenic basis of isolated gonadotropin-releasing hormone deficiency.

Proceedings of the National Academy of Sciences of the United States of America - 24 Aug 2010

Sykiotis Gerasimos P, Plummer Lacey, Hughes Virginia A, Au Margaret, Durrani Sadia, Nayak-Young Sadhana, Dwyer Andrew A, Quinton Richard, Hall Janet E, Gusella James F, Seminara Stephanie B, Crowley William F, Pitteloud Nelly

Abstract excerpt

Between the genetic extremes of rare monogenic and common polygenic diseases lie diverse oligogenic disorders involving mutations in more than one locus in each affected individual. Elucidating the principles of oligogenic inheritance and mechanisms of genetic interactions could help unravel the newly appreciated role of rare sequence variants in polygenic disorders. With few exceptions, however, the precise...

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Source

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Identifiers

PMID: 20696889
DOI: 10.1073/pnas.1009622107
PMCID: PMC2930591

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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