Article
[Mitochondrial recessive ataxia syndrome (MIRAS) and valproate toxicity].
Duodecim; laaketieteellinen aikakauskirja - 1 Jan 2010
Hakonen Anna H, Isohanni Pirjo, Rantamäki Maria, Kälviäinen Reetta, Nordin Arno, Uusimaa Johanna, Paetau Anders, Udd Bjarne, Pihko Helena, Wartiovaara Anu
Abstract excerpt
The clinical phenotypes vary considerably and can be divided into three groups: 1) childhood-onset encephalopathy and hepatopathy, 2) juvenile onset refractory epilepsy and migraine-like headaches, and 3) adult-onset ataxia and neuropathy with additional symptoms such as psychiatric symptoms and cognitive impairment. The life-threatening MIRAS epilepsy should be actively treated, as it is associated with poor...
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