Article
Tnf-α expression and promoter sequences reflect the balance of tolerance/resistance to Puumala hantavirus infection in European bank vole populations.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2010
Guivier Emmanuel, Galan Maxime, Salvador Alexis Ribas, Xuéreb Anne, Chaval Yannick, Olsson Gert E, Essbauer Sandra, Henttonen Heikki, Voutilainen Liina, Cosson Jean-François, Charbonnel Nathalie
Abstract excerpt
The tumor necrosis factor-alpha (TNF-α) influences the ability to limit parasite infection but its over-production might result in inflammatory disorders. The level of Tnf-α gene expression could thus mediate a balance of tolerance/resistance to infections. This study focused on Puumala hantavirus (PUUV) infection in its rodent host, the bank vole (Myodes glareolus). In humans, PUUV is responsible of a mild form...
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