Article
Association between the DQA MHC class II gene and Puumala virus infection in Myodes glareolus, the bank vole.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jul 2008
Deter Julie, Bryja Josef, Chaval Yannick, Galan Maxime, Henttonen Heikki, Laakkonen Juha, Voutilainen Liina, Vapalahti Olli, Vaheri Antti, Salvador Alexis Ribas, Morand Serge, Cosson Jean-François, Charbonnel Nathalie
Abstract excerpt
Puumala virus (PUUV) is a hantavirus specifically harboured by the bank vole, Myodes (earlier Clethrionomys) glareolus. It causes a mild form of hemorrhagic fever with renal syndrome (HFRS) in humans, called Nephropathia epidemica (NE). The clinical severity of NE is variable among patients and depends on their major histocompatibility complex (MHC) genetic background. In this study we investigated the potential...
Topics
- Animals
- Arvicolinae
- Genes, MHC Class II
- Genotype
- HLA-DQ Antigens
- HLA-DQ alpha-Chains
- Hemorrhagic Fever with Renal Syndrome
- Phylogeny
- Puumala virus
- Rodent Diseases
- Seroepidemiologic Studies