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Article

Exploring the genetic basis of variation in gene predictions with a synthetic association study.

PloS one - 29 Jul 2010

Levin Tera C, Glazer Andrew M, Pachter Lior, Brem Rachel B, Eisen Michael B

Abstract excerpt

Identifying DNA polymorphisms that affect molecular processes like transcription, splicing, or translation typically requires genotyping and experimentally characterizing tissue from large numbers of individuals, which remains expensive and time consuming. Here we introduce an alternative strategy: a "synthetic association study" in which we computationally predict molecular phenotypes on artificial genomes...

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PMID: 20686598
DOI: 10.1371/journal.pone.0011645
PMCID: PMC2912228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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