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Participation of DNA-PKcs in DSB Repair after Exposure to High- and Low-LET Radiation

17 Jun 2010

Abstract excerpt

Cellular lesions (e.g. DSBs) are induced into DNA upon exposure to radiation, with DSB complexity increasing with radiation ionization density. Using M059K and M059J human glioblastoma cells (proficient and deficient in DNA-PKcs activity, respectively), we investigated the repair of DNA damage, including DSBs, induced by high- and low-LET radiation [gamma rays, alpha particles and high-charge and energy (HZE)...

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PMID: 20681786
DOI: 10.1667/rr2071.1

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