Molecular identification of Trypanosoma cruzi discrete typing units in end-stage chronic Chagas heart disease and reactivation after heart transplantation.

doi:10.1086/655680

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Article

Molecular identification of Trypanosoma cruzi discrete typing units in end-stage chronic Chagas heart disease and reactivation after heart transplantation.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Sept 2010

Burgos Juan Miguel, Diez Mirta, Vigliano Carlos, Bisio Margarita, Risso Marikena, Duffy Tomás, Cura Carolina, Brusses Betina, Favaloro Liliana, Leguizamon María Susana, Lucero Raul Horacio, Laguens Ruben, Levin Mariano Jorge, Favaloro Roberto, Schijman Alejandro Gabriel

Abstract excerpt

BACKGROUND: One hundred years after the discovery of Chagas disease, it remains a major neglected tropical disease. Chronic Chagas heart disease (cChHD) is the most severe manifestation. Heart transplantation is the proper treatment for end-stage heart failure, although reactivation of disease may result after receipt of immunosuppressive therapy. T. cruzi strains cluster into 6 discrete typing units (DTUs; I-VI)...

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PMID: 20645859
DOI: 10.1086/655680

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