Article
Characterization of deletions at the retinoblastoma locus in patients with bilateral retinoblastoma.
American journal of medical genetics - 1 May 1991
Kloss K, Währisch P, Greger V, Messmer E, Fritze H, Höpping W, Passarge E, Horsthemke B
Abstract excerpt
DNA samples from 92 unrelated patients with bilateral retinoblastoma were analyzed by Southern blot hybridization with cDNA and genomic clones of the retinoblastoma (RB-1) gene. Qualitative and quantitative evaluation of the Southern blot patterns showed a deletion of all or part of the RB-1 gene...
Topics
- Blotting, Southern
- Chromosome Deletion
- DNA
- Eye Neoplasms
- Genes, Retinoblastoma
- Genetic Markers
- Humans
- Mutation
- Restriction Mapping
- Retinoblastoma