Article
Isolation and characterization of microparticles in sputum from cystic fibrosis patients.
Respiratory research - 9 Jul 2010
Porro Chiara, Lepore Silvia, Trotta Teresa, Castellani Stefano, Ratclif Luigi, Battaglino Anna, Di Gioia Sante, Martínez Maria C, Conese Massimo, Maffione Angela B
Abstract excerpt
BACKGROUND: Microparticles (MPs) are membrane vesicles released during cell activation and apoptosis. MPs have different biological effects depending on the cell from they originate. Cystic fibrosis (CF) lung disease is characterized by massive neutrophil granulocyte influx in the airways, their activation and eventually apoptosis. We investigated on the presence and phenotype of MPs in the sputum, a rich...
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