Article
Recurrent inversion events at 17q21.31 microdeletion locus are linked to the MAPT H2 haplotype.
Cytogenetic and genome research - 1 Jan 2010
Rao P N, Li W, Vissers L E L M, Veltman J A, Ophoff R A
Abstract excerpt
The chromosomal band 17q21.31, containing the microtubule-associated protein tau (MAPT) gene, is a hotspot for chromosomal rearrangements. It is known to contain a common inversion polymorphism of approximately 900 kb in populations with European ancestry. The inverted configuration is linked to a distinct MAPT haplotype, H2, which is relatively common in Europeans but nearly absent in Asian and African...
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