HLA genotyping in the international Type 1 Diabetes Genetics Consortium.

doi:10.1177/1740774510373494

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Article

HLA genotyping in the international Type 1 Diabetes Genetics Consortium.

Clinical trials (London, England) - 1 Jan 2010

Mychaleckyj Josyf C, Noble Janelle A, Moonsamy Priscilla V, Carlson Joyce A, Varney Michael D, Post Jeff, Helmberg Wolfgang, Pierce June J, Bonella Persia, Fear Anna Lisa, Lavant Eva, Louey Anthony, Boyle Sean, Lane Julie A, Sali Paul, Kim Samuel, Rappner Rebecca, Williams Dustin T, Perdue Letitia H, Reboussin David M, Tait Brian D, Akolkar Beena, Hilner Joan E, Steffes Michael W, Erlich Henry A

Abstract excerpt

BACKGROUND: Although human leukocyte antigen (HLA) DQ and DR loci appear to confer the strongest genetic risk for type 1 diabetes, more detailed information is required for other loci within the HLA region to understand causality and stratify additional risk factors. The Type 1 Diabetes Genetics Consortium (T1DGC) study design included high-resolution genotyping of HLA-A, B, C, DRB1, DQ, and DP loci in all...

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PMID: 20595243
DOI: 10.1177/1740774510373494
PMCID: PMC2917849

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