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Article

KRAS mutation and microsatellite instability in endometrial adenocarcinomas showing MELF-type myometrial invasion.

Journal of clinical pathology - 1 Jul 2010

Stewart C J R, Amanuel B, Grieu F, Carrello A, Iacopetta B

Abstract excerpt

BACKGROUND: Some uterine endometrioid adenocarcinomas exhibit a distinctive morphological phenotype characterised by the formation of microcystic, elongated and fragmented (MELF) glands. Immunohistochemical studies have suggested that MELF-type changes represent an epithelial-mesenchymal transition which has been associated with KRAS activation in various tumours. AIMS: To investigate the molecular...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20591910
DOI: 10.1136/jcp.2009.069500

Genes

KRAS
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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