Article
Common variants in the regulative regions of GRIA1 and GRIA3 receptor genes are associated with migraine susceptibility.
BMC medical genetics - 25 Jun 2010
Formicola Daniela, Aloia Andrea, Sampaolo Simone, Farina Olimpia, Diodato Daria, Griffiths Lyn R, Gianfrancesco Fernando, Di Iorio Giuseppe, Esposito Teresa
Abstract excerpt
BACKGROUND: Glutamate is the principal excitatory neurotransmitter in the central nervous system which acts by the activation of either ionotropic (AMPA, NMDA and kainate receptors) or G-protein coupled metabotropic receptors. Glutamate is widely accepted to play a major role in the path physiology of migraine as implicated by data from animal and human studies. Genes involved in synthesis, metabolism and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.