Article
Ex vivo organ culture of adipose tissue for in situ mobilization of adipose-derived stem cells and defining the stem cell niche.
Journal of cellular physiology - 1 Sept 2010
Yang Young-Il, Kim Hyeong-In, Choi Min-Young, Son Sung-Hee, Seo Min-Jeong, Seo Ji-Yeon, Jang Won-Hee, Youn Young-Chul, Choi Kang-Joo, Cheong Soon-Ho, Shelby Jane
Abstract excerpt
In spite of the advances in the knowledge of adipose-derived stem cells (ASCs), in situ location of ASCs and the niche component of adipose tissue (AT) remain controversial due to the lack of an appropriate culture system. Here we describe a fibrin matrix-supported three-dimensional (3D) organ culture system for AT which sustains the ASC niche and allows for in situ mobilization and expansion of ASCs in vitro. AT...
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