Nuclear factor κB transcription factors are coexpressed and convey a poor outcome in ovarian cancer

Abstract excerpt

BACKGROUND: Recent work has suggested a role for nuclear factor kappaB (NF-kappaB) in the propagation of ovarian cancer cell lines, but the significance and mechanism of NF-kappaB in ovarian cancer is unknown. The authors hypothesized that the NF-kappaB pathway is over activated in aggressive ovarian cancers. METHODS: The levels of 3 NF-kappaB transcription factors, the activating inhibitors of NF-kappaB...

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