Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells.

Cancer letters - 1 Nov 2010

Zheng Hang, Liu Anling, Liu Bin, Li Minghui, Yu Hailang, Luo Xiaojun

Abstract excerpt

The purpose of this work is to study mechanisms underlying anti-tumor effects of farnesyltransferase inhibitors (FTIs) in non-small cell lung cancer (NSCLC). We demonstrate that mRNA and protein levels of Ras homologue enriched in brain (Rheb) are highly expressed both in NSCLC tissues and in NSC...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cisplatin
Share to Farnesyltranstransferase
Share to Mechanistic Target of Rapamycin Complex 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Monomeric GTP-Binding Proteins

Share to Multiprotein Complexes

Share to Neuropeptides

Share to Piperidines

Share to Quinolones

Source

Identifiers

PMID: 20554106
DOI: 10.1016/j.canlet.2010.05.004

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20554106-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ras homologue enriched in brain is a critical target of farnesyltransferase inhibitors in non-small cell lung cancer cells.PMID 20554106Read ↗

miR-199a-3p/5p regulate tumorgenesis via targeting Rheb in non-small cell lung cancer.Semantic proximity Read ↗

EREG increases stemness associated genes expression and promotes Chemoresistance of non-small cell lung cancer via ERK signalingSemantic proximity Read ↗

Oncogenic KRAS-induced epiregulin overexpression contributes to aggressive phenotype and is a promising therapeutic target in non-small-cell lung cancer.Semantic proximity Read ↗

The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.Semantic proximity Read ↗

RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer.Semantic proximity Read ↗

Antineoplastic Effects of Erufosine on Small and Non-Small Lung Cancer Cells Through Induction of Apoptosis and Cell Cycle ArrestSemantic proximity Read ↗

Epiregulin increases stemness-associated genes expression and promotes chemoresistance of non-small cell lung cancer via ERK signalingSemantic proximity Read ↗

An oncogenic mutant of RHEB, RHEB Y35N, exhibits an altered interaction with BRAF resulting in cancer transformation.Semantic proximity Read ↗

Cholesterol promotes EGFR-TKIs resistance in NSCLC by inducing EGFR/Src/Erk/SP1 signaling-mediated ERRα re-expression.Semantic proximity Read ↗

The Root Extract of Peucedanum praeruptorum Dunn Exerts Anticancer Effects in Human Non-Small-Cell Lung Cancer Cells with Different EGFR Mutation Statuses by Suppressing MET Activity.Semantic proximity Read ↗

Pemetrexed induces ROS generation and cellular senescence by attenuating TS-mediated thymidylate metabolism to reverse gefitinib resistance in non-small cell lung cancerSemantic proximity Read ↗

Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLCSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.