Article
Genetic variants in selected pre-microRNA genes and the risk of squamous cell carcinoma of the head and neck.
Cancer - 15 Oct 2010
Liu Zhensheng, Li Guojun, Wei Sheng, Niu Jiangong, El-Naggar Adel K, Sturgis Erich M, Wei Qingyi
Abstract excerpt
BACKGROUND: Single nucleotide polymorphisms (SNPs) in microRNAs (miRNAs) may alter the processing, transcription, and expression of miRNAs and, thus, may contribute to cancer development. The authors hypothesized that common polymorphisms in pre-miRNAs are associated individually and (more likely) collectively with the risk of squamous cell carcinoma of the head and neck (SCCHN). METHODS: The authors genotyped 4...
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