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Structure of the Rift Valley fever virus nucleocapsid protein reveals another architecture for RNA encapsidation

14 Jun 2010

Abstract excerpt

Rift Valley fever virus (RVFV) is a negative-sense RNA virus (genus Phlebovirus, family Bunyaviridae) that infects livestock and humans and is endemic to sub-Saharan Africa. Like all negative-sense viruses, the segmented RNA genome of RVFV is encapsidated by a nucleocapsid protein (N). The 1.93-A crystal structure of RVFV N and electron micrographs of ribonucleoprotein (RNP) reveal an encapsidated genome of...

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PMID: 20547879
DOI: 10.1073/pnas.1001760107

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