Article
Polymorphisms of the macrophage migration inhibitory factor gene in a UK population with Type 1 diabetes mellitus.
Diabetic medicine : a journal of the British Diabetic Association - 1 Feb 2010
Martin R J L, Savage D A, Carson D J, McKnight A J, Maxwell A P, Patterson C C
Abstract excerpt
AIMS: Macrophage migration inhibitory factor (MIF) is a potent pro-inflammatory cytokine whose production is transcriptionally regulated by glucose. Experimental data from both Type 1 diabetes mellitus (T1D) patients and animal models suggests a role for MIF in the development of T1D. The aim of this study was to employ gene resequencing to identify common DNA polymorphisms in the MIF gene and subsequently assess...
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