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Article

The CD4+ lymphopenic sarcoidosis phenotype is highly responsive to anti-tumor necrosis factor-{alpha} therapy.

Chest - 1 Jun 2010

Crouser Elliott D, Lozanski Gerard, Fox Charity C, Hauswirth David W, Raveendran Rekha, Julian Mark W

Abstract excerpt

The treatment options for patients with sarcoidosis are presently limited, and it is unclear which treatments are most effective for any given patient. We have identified a sarcoidosis phenotype characterized by CD4(+) lymphopenia and resistance to conventional immunosuppressants, such as corticosteroids and methotrexate. Based on recent reports linking tumor necrosis factor (TNF)-alpha to regulatory T-cell...

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Share to Antibodies, Monoclonal
Share to CD4-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Infliximab

Share to Infusions, Intravenous

Share to Lymphocyte Count

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Source

Identifiers

PMID: 20525654
DOI: 10.1378/chest.09-2576

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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