Article
WHO-defined 'myelodysplastic syndrome with isolated del(5q)' in 88 consecutive patients: survival data, leukemic transformation rates and prevalence of JAK2, MPL and IDH mutations.
Leukemia - 1 Jul 2010
Patnaik M M, Lasho T L, Finke C M, Gangat N, Caramazza D, Holtan S G, Pardanani A, Knudson R A, Ketterling R P, Chen D, Hoyer J D, Hanson C A, Tefferi A
Abstract excerpt
The 2008 World Health Organization (WHO) criteria were used to identify 88 consecutive Mayo Clinic patients with 'myelodysplastic syndrome with isolated del(5q)' (median age 74 years; 60 females). In all, 60 (68%) patients were followed up to the time of their death. Overall median survival was 66 months; leukemic transformation was documented in five (5.7%) cases. Multivariable analysis identified age >or=70...
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