Article
Heme biosynthesis is coupled to electron transport chains for energy generation.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jun 2010
Möbius Kalle, Arias-Cartin Rodrigo, Breckau Daniela, Hännig Anna-Lena, Riedmann Katrin, Biedendieck Rebekka, Schröder Susanne, Becher Dörte, Magalon Axel, Moser Jürgen, Jahn Martina, Jahn Dieter
Abstract excerpt
Cellular energy generation uses membrane-localized electron transfer chains for ATP synthesis. Formed ATP in turn is consumed for the biosynthesis of cellular building blocks. In contrast, heme cofactor biosynthesis was found driving ATP generation via electron transport after initial ATP consumption. The FMN enzyme protoporphyrinogen IX oxidase (HemG) of Escherichia coli abstracts six electrons from its...
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