Article
A critical appraisal of human genotyping for pain therapy.
Trends in pharmacological sciences - 1 Jul 2010
Lötsch Jörn, Geisslinger Gerd
Abstract excerpt
Despite intensive research, genetics-based personalized pain therapy has yet to emerge. Monogenetic heredity seems to be restricted to very rare and extreme phenotypes, whereas common phenotypes are very complex and multigenetic. Many common variants, of which only a fraction have been identified so far, produce only minor effects that are sometimes partly cancelled out. For most clinical settings and analgesic...
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