Article
A novel PS1 gene mutation in a large Aboriginal kindred.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques - 1 May 2010
Butler Rachel, Beattie B Lynn, Thong Umamon Puang, Dwosh Emily, Guimond Colleen, Feldman Howard H, Hsiung Ging-Yuek Robin, Rogaeva Ekaterina, St George-Hyslop Peter, Sadovnick A Dessa
Abstract excerpt
BACKGROUND: There is currently little information on the genetic epidemiology of Alzheimer disease (AD) among North American Aboriginal populations. No cases of familial AD (FAD) in these populations have been published to date. METHODS: Here, we describe a large North American Aboriginal kindred with early onset FAD (EOFAD) in which genetic testing was done. RESULTS AND CONCLUSIONS: A novel Presenilin 1 (PS1)...
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