Article
Systematic resequencing of X-chromosome synaptic genes in autism spectrum disorder and schizophrenia.
Molecular psychiatry - 1 Aug 2011
Piton A, Gauthier J, Hamdan F F, Lafrenière R G, Yang Y, Henrion E, Laurent S, Noreau A, Thibodeau P, Karemera L, Spiegelman D, Kuku F, Duguay J, Destroismaisons L, Jolivet P, Côté M, Lachapelle K, Diallo O, Raymond A, Marineau C, Champagne N, Xiong L, Gaspar C, Rivière J-B, Tarabeux J, Cossette P, Krebs M-O, Rapoport J L, Addington A, Delisi L E, Mottron L, Joober R, Fombonne E, Drapeau P, Rouleau G A
Abstract excerpt
Autism spectrum disorder (ASD) and schizophrenia (SCZ) are two common neurodevelopmental syndromes that result from the combined effects of environmental and genetic factors. We set out to test the hypothesis that rare variants in many different genes, including de novo variants, could predispose to these conditions in a fraction of cases. In addition, for both disorders, males are either more significantly or...
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