Article
Bone marrow morphologic features in polycythemia vera with JAK2 exon 12 mutations.
American journal of clinical pathology - 1 Jun 2010
Lakey Meredith A, Pardanani Animesh, Hoyer James D, Nguyen Phuong L, Lasho Terra L, Tefferi Ayalew, Hanson Curtis A
Abstract excerpt
The diagnosis of polycythemia vera (PV) requires the integration of clinical and laboratory findings, bone marrow morphologic features, and JAK2 analysis. JAK2(V617F) (exon 14) mutation is found in 95% of PV cases. Functionally similar mutations in JAK2 exon 12 have also been described, but a thorough bone marrow study has not been done. We identified 7 PV cases with exon 12 mutations; all had hypercellular bone...
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