Article
Molecular mechanisms of pathogenesis of Parkinson's disease.
International review of cell and molecular biology - 1 Jan 2010
Shadrina M I, Slominsky P A, Limborska S A
Abstract excerpt
Parkinson's disease is a complex disease characterized by a progressive degeneration of nigrostriatal dopaminergic neurons. The development of this condition is defined by the interaction between the genetic constitution of an organism and environmental factors. Analysis of the genes associated with development of monogenic forms of disease has allowed pointing out several mechanisms involved in Parkinson's...
Topics
- Animals
- Dopamine
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Lysosomes
- Mitochondria
- Models, Neurological
- Mutation
- Neurons
- Oxidative Stress
- Parkinson Disease