Article
The association between the PTPN22 1858C>T variant and type 1 diabetes depends on HLA risk and GAD65 autoantibodies.
Genes and immunity - 1 Jul 2010
Maziarz M, Janer M, Roach J C, Hagopian W, Palmer J P, Deutsch K, Sanjeevi C B, Kockum I, Breslow N, Lernmark A
Abstract excerpt
The single nucleotide polymorphism 1858C>T in the PTPN22 gene is associated with type 1 diabetes (T1D) in several populations. Earlier reports have suggested that the association may be modified by human leukocyte antigen (HLA), as well as by islet autoantibodies. In a large case-control study of Swedish incident T1D patients and controls, 0-34 years of age, we tested whether the odds ratio (OR) measure of...
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