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Article

Factor IX ectopically expressed in platelets can be stored in alpha-granules and corrects the phenotype of hemophilia B mice.

Blood - 26 Aug 2010

Zhang Guowei, Shi Qizhen, Fahs Scot A, Kuether Erin L, Walsh Christopher E, Montgomery Robert R

Abstract excerpt

We developed 2bF9 transgenic mice in a hemophilia B mouse model with the expression of human factor IX (FIX) under control of the platelet-specific integrin alphaIIb promoter, to determine whether ectopically expressing FIX in megakaryocytes can enable the storage of FIX in platelet alpha-granules and corrects the murine hemophilia B phenotype. FIX was detected in the platelets and plasma of 2bF9 transgenic mice...

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Source

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Identifiers

PMID: 20445020
DOI: 10.1182/blood-2009-11-255612
PMCID: PMC2938234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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