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Article

Clinical evaluation and mitochondrial DNA sequence analysis in three Chinese families with Leber's hereditary optic neuropathy.

Biochemical and biophysical research communications - 1 Jul 2005

Qian Yaping, Zhou Xiangtian, Hu Yongwu, Tong Yi, Li Ronghua, Lu Fan, Yang Huanming, Mo Jun Qin, Qu Jia, Guan Min-Xin

Abstract excerpt

We report here the clinical, genetic, and molecular characterization of three Chinese families (WZ4, WZ5, and WZ6) with Leber's hereditary optic neuropathy (LHON). Clinical and genetic evaluations revealed the variable severity and age-of-onset in visual impairment in these families. Penetrances of visual impairment in these Chinese families were 33.3%, 35.7%, and 35.5%, respectively, with an average 34.8%....

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Identifiers

PMID: 15896721
DOI: 10.1016/j.bbrc.2005.05.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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