Article
Experimental identification of microRNA targets on the 3' untranslated region of human FMR1 gene.
Journal of neuroscience methods - 30 Jun 2010
Yi Yong-Hong, Sun Xun-Sha, Qin Jia-Ming, Zhao Qi-Hua, Liao Wei-Ping, Long Yue-Sheng
Abstract excerpt
FMR1 gene plays an important role in the development of central nervous system. Down-regulation of the FMR1 expression leads to fragile X syndrome. MicroRNAs (miRNAs) can repress gene expression by base pairing with their mRNA targets. By computer programs analysis, five miRNAs: miR-19a, miR-19b, miR-142, miR-302b* and miR-323-3p potentially target to different sites on the FMR1 3' untranslated region (3' UTR),...
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