Article
Molecular monitoring in patients with chronic myelogenous leukemia.
Current hematologic malignancy reports - 1 Apr 2008
Saglio Giuseppe, Ulisciani Stefano, Fava Milena, Gottardi Enrico, Cilloni Daniela
Abstract excerpt
Imatinib has revolutionized the treatment of chronic myelogenous leukemia (CML). Given the high rates of complete cytogenetic remission achieved with imatinib therapy, molecular monitoring of BCR-ABL transcript levels by real-time quantitative polymerase chain reaction has become the method of choice to assess the amount of residual disease below the cytogenetic threshold. BCR-ABL transcript levels measured at...
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