Article
Using trajectory analyses to refine phenotype for genetic association: conduct problems and the serotonin transporter (5HTTLPR).
Psychiatric genetics - 1 Oct 2010
Sakai Joseph T, Boardman Jason D, Gelhorn Heather L, Smolen Andrew, Corley Robin P, Huizinga David, Menard Scott, Hewitt John K, Stallings Michael C
Abstract excerpt
BACKGROUND: Conduct disorder is a serious, relatively common disorder of childhood and adolescence. Findings from genetic association studies searching for genetic determinants of the liability toward such behaviors have been inconsistent. One possible explanation for differential results is that most studies define phenotype from a single assessment; for many adolescents conduct problems decrease in severity...
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