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Article

The prevalence and natural history of dominant optic atrophy due to OPA1 mutations.

Ophthalmology - 1 Aug 2010

Yu-Wai-Man Patrick, Griffiths Philip G, Burke Ailbhe, Sellar Peter W, Clarke Michael P, Gnanaraj Lawrence, Ah-Kine Desiree, Hudson Gavin, Czermin Birgit, Taylor Robert W, Horvath Rita, Chinnery Patrick F

Abstract excerpt

PURPOSE: Autosomal dominant optic atrophy (DOA) is a major cause of visual impairment in young adults that is characterized by selective retinal ganglion cell loss. To define the prevalence and natural history of this optic nerve disorder, we performed a population-based epidemiologic and molecular study of presumed DOA cases in the north of England. DESIGN: Case series. PARTICIPANTS: Seventy-six affected...

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Source

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Identifiers

PMID: 20417570
DOI: 10.1016/j.ophtha.2009.12.038
PMCID: PMC4040407

Genes

OPA1
OPA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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