Article
Systems biology through mouse imaging centers: experience and new directions.
Annual review of biomedical engineering - 15 Aug 2010
Henkelman R Mark
Abstract excerpt
The completed sequencing of genomes has forced upon us the challenge of understanding how the detailed information in the genome gives rise to the specific characteristics--phenotype--of the individual. This is crucial for understanding not only normal development but also, from a medical perspective, the genetic basis of disease. Much of the mammalian genome-to-phenotype relationship will be worked out in the...
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