Article
Analysis of three functional polymorphisms in relation to osteoporosis phenotypes: replication in a Spanish cohort.
Calcified tissue international - 1 Jul 2010
Agueda Lídia, Urreizti Roser, Bustamante Mariona, Jurado Susana, Garcia-Giralt Natàlia, Díez-Pérez Adolfo, Nogués Xavier, Mellibovsky Leonardo, Grinberg Daniel, Balcells Susana
Abstract excerpt
Osteoporosis is a complex disease involving many putative genetic factors. Association analysis of functional SNPs in candidate genes is an important tool for their identification. However, this approach is affected by limited power, population stratification, and other drawbacks that lead to discordant results. Replication in independent cohorts is essential. We performed association analyses of three functional...
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