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Mouse Mammary Tumor Virus–like Sequences in Human Breast Cancer

13 Apr 2010

Abstract excerpt

Mouse mammary tumor virus (MMTV) sequences have been reported to be present in some human breast cancers, but it is unclear whether they have any causal role. In mice, MMTV promotes tumor formation indirectly by insertional mutagenesis of Wnt oncogenes that lead to their activation. In this study, we investigated the status of Wnt-1 in human breast cancers harboring MMTV-like sequences encoding viral envelope...

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PMID: 20388779
DOI: 10.1158/0008-5472.can-09-4160

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