Article
Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis
12 Apr 2010
Abstract excerpt
The autosomal recessive congenital ichthyoses are a family of related diseases, causing a severe defect in the barrier function of the epidermis. Neonates are usually born as collodion babies, but later form scales characteristic of the disease, due to a combination of thickening of the cornified layer and an increase in the production of non-polar lipids. Current treatments of choice are exfoliative creams and...
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