Article
Stem cell plasticity revisited: the continuum marrow model and phenotypic changes mediated by microvesicles.
Experimental hematology - 1 Jul 2010
Quesenberry Peter J, Dooner Mark S, Aliotta Jason M
Abstract excerpt
The phenotype of marrow hematopoietic stem cells is determined by cell-cycle state and microvesicle entry into the stem cells. The stem cell population is continually changing based on cell-cycle transit and can only be defined on a population basis. Purification of marrow stem cells only addresses the heterogeneity of these populations. When whole marrow is studied, the long-term repopulating stem cells are in...
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