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Article

Effects in neocortical neurons of mutations of the Na(v)1.2 Na+ channel causing benign familial neonatal-infantile seizures.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 4 Oct 2006

Scalmani Paolo, Rusconi Raffaella, Armatura Elena, Zara Federico, Avanzini Giuliano, Franceschetti Silvana, Mantegazza Massimo

Abstract excerpt

Mutations of voltage-gated Na+ channels are the most common cause of familial epilepsy. Benign familial neonatal-infantile seizures (BFNIS) is an epileptic trait of the early infancy, and it is the only well characterized epileptic syndrome caused exclusively by mutations of Na(V)1.2 Na+ channels, but no functional studies of BFNIS mutations have been done. The comparative study of the functional effects and the...

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Identifiers

PMID: 17021166
DOI: 10.1523/JNEUROSCI.2476-06.2006
PMCID: PMC6674637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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