Article
Male circumcision decreases acquisition and increases clearance of high-risk human papillomavirus in HIV-negative men: a randomized trial in Rakai, Uganda.
The Journal of infectious diseases - 15 May 2010
Gray Ronald H, Serwadda David, Kong Xiangrong, Makumbi Frederick, Kigozi Godfrey, Gravitt Patti E, Watya Stephen, Nalugoda Fred, Ssempijja Victor, Tobian Aaron A R, Kiwanuka Noah, Moulton Lawrence H, Sewankambo Nelson K, Reynolds Steven J, Quinn Thomas C, Iga Boaz, Laeyendecker Oliver, Oliver Amy E, Wawer Maria J
Abstract excerpt
METHODS: Uncircumcised human immunodeficiency virus (HIV)-negative men aged 15-49 years were randomized to immediate circumcision (intervention arm, 441 subjects) or delayed circumcision (control arm, 399 subjects). Human papillomavirus (HPV) was detected by Roche HPV Linear Array at enrollment, and at 6, 12, and 24 months. Incident high-risk HPV (HR-HPV) was estimated in men who acquired a new HR-HPV genotype....
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