Article
Low serum vitamin K in PXE results in defective carboxylation of mineralization inhibitors similar to the GGCX mutations in the PXE-like syndrome.
Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2010
Vanakker Olivier M, Martin Ludovic, Schurgers Leon J, Quaglino Daniela, Costrop Laura, Vermeer Cees, Pasquali-Ronchetti Ivonne, Coucke Paul J, De Paepe Anne
Abstract excerpt
Soft-tissue mineralization is a tightly regulated process relying on the activity of systemic and tissue-specific inhibitors and promoters of calcium precipitation. Many of these, such as matrix gla protein (MGP) and osteocalcin (OC), need to undergo carboxylation to become active. This post-tran...
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