Article
Osteoblastic bone lesions developing during treatment with erlotinib indicate major response in patients with non-small cell lung cancer: a brief report.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2010
Lind Joline S W, Postmus Pieter E, Smit Egbert F
Abstract excerpt
BACKGROUND: The osteoblastic bone flare or response is the paradoxical phenomenon of increase in the quantity and/or density of bone lesions in the presence of well-documented disease response to treatment in other tumor sites. It results from the rapid repair and increased osteoblastic activity in bone metastases responding to therapy and therefore represents treatment efficacy. Nevertheless, no reliable markers...
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