Article
Response to adefovir depends on mutation patterns in precore region, basal core promoter and reverse transcriptase, and on-treatment responses in Lamivudine-resistant chronic hepatitis B patients.
Intervirology - 1 Jan 2010
Song Byung-Cheol, Cui Xiu Ji, Shin Jung Woo, Park Neung Hwa, Cho Yoo-Kyung, Song Hyun Joo, Hyun Soyoung, Jeong Seung Uk, Choi Eun Kwang, Kim Heung Up
Abstract excerpt
OBJECTIVE: In vitro studies showed that mutations in the basal core promoter (BCP) or precore (PC) region restore the replication inefficiency of the lamivudine-resistant mutant. The aim of this study was to clarify the effect of molecular characteristics on the antiviral response to adefovir in patients with lamivudine-resistant chronic hepatitis B (CHB). METHODS: Sixty-six lamivudine-resistant patients who were...
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