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Article

Precore stop codon mutation of hepatitis B virus is associated with low breakthrough rate following long-term lamivudine therapy.

Journal of gastroenterology and hepatology - 1 Jun 2005

Shin Jung Woo, Chung Young-Hwa, Choi Min Hee, Kim Jeong A, Ryu Soo Hyung, Jang Myoung Kuk, Kim In Sook, Park Neung Hwa, Lee Han Chu, Lee Yung Sang, Suh Dong Jin

Abstract excerpt

BACKGROUND: Frequent viral breakthroughs limit the usefulness of lamivudine in the treatment of chronic hepatitis B (CHB). The purpose of the present study was to evaluate the effects of precore stop codon mutation (G to A mutation at nucleotide 1896; A(1896)) of hepatitis B virus (HBV) on the occurrence of viral breakthrough following lamivudine therapy. METHODS: Among 260 consecutive CHB patients treated with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B, Chronic

Share to Hepatitis B e Antigens

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Identifiers

PMID: 15946130
DOI: 10.1111/j.1440-1746.2005.03824.x

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