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Gukulenins A and B, Cytotoxic Tetraterpenoids from the Marine Sponge <i>Phorbas gukulensis</i>

16 Mar 2010

Abstract excerpt

Gukulenins A (1) and B (2), both having an unprecedented skeleton with a bis-tropolone moiety, were isolated from the Korean marine sponge Phorbas gukulensis. They exhibited significant cytotoxicity against human pharynx, stomach, colon, and renal cancer cell lines in the range 0.05-0.80 microM.

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PMID: 20232859
DOI: 10.1021/np900606h

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