Enhancement of Biofilm Formation by Subinhibitory Concentrations of Macrolides in <i>icaADBC-</i> Positive and -Negative Clinical Isolates of <i>Staphylococcus epidermidis</i>

Abstract excerpt

Biofilm formation in Staphylococcus epidermidis is mediated by icaADBC-dependent and -independent pathways. Subinhibitory concentrations of erythromycin, azithromycin, and clarithromycin enhanced, in a dose-dependent manner, the level of biofilm formation by 20% (21/105 isolates) by macrolide-resistant ica-positive and -negative isolates tested in vitro. The presence of ica, however, apparently produced an...

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