Article
Sequence analysis of HLA-Bw53, a common West African allele, suggests an origin by gene conversion of HLA-B35.
Human immunology - 1 Feb 1991
Allsopp C E, Hill A V, Kwiatkowski D, Hughes A, Bunce M, Taylor C J, Pazmany L, Brewster D, McMichael A J, Greenwood B M
Abstract excerpt
In the West African population of the Gambia the class I antigen HLA-Bw53 is found at high frequency. We used the polymerase chain reaction to amplify cDNA from an individual homozygous for this allele and determined the nucleotide sequence of the polymorphic alpha 1 and alpha 2 domains. The HLA-Bw53 sequence is identical to HLA-B35 except for a short sequence at the 3' end of exon 2 (encoding the alpha 1 domain)...
Topics
- Adult
- Alleles
- Amino Acid Sequence
- Base Sequence
- DNA
- Gambia
- Gene Conversion
- HLA Antigens
- HLA-B Antigens
- HLA-B35 Antigen
- Humans