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Article

Expression of IGF2 and IGF receptor mRNA in bovine nuclear transferred embryos

1 Aug 2003

Abstract excerpt

Incomplete reprogramming of the donor cell nucleus after nuclear transfer (NT) probably leads to the abnormal expression of developmentally important genes. This may be responsible for the low efficiency of cloned animal production. Insulin-like growth factor 2 (IGF2) and IGF2 receptor (IGF2R) are imprinted genes that play important roles in preimplantation development. To obtain an insight into abnormal gene...

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PMID: 14640189
DOI: 10.1017/s0967199403002296

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