Article
Association between male infertility and androgen receptor mutations in Brazilian patients.
Genetics and molecular research : GMR - 26 Jan 2010
Melo C O A, Danin A R, Silva D M, Tacon J A, Moura K K V O, Costa E O A, da Cruz A D
Abstract excerpt
The androgen receptor is encoded by a single-copy gene located in the long arm of the X chromosome (Xq11-12); it consists of eight exons and encodes an intracellular transcription factor that belongs to the steroid/nuclear receptor superfamily. Disturbances in the function of the androgen receptor can lead to several forms of male pseudohermaphroditism, such as androgen insensitivity syndrome, which can lead to...
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